The 1,070 km road trip from Rome to Sicily will take around 13 hours to drive. Notable stops are Naples, Salerno, Messina, Catania, Syracuse, Anagni, Amalfi Coast, Mount Etna, Mount Vesuvius, Civitavecchia, Palermo and Orsini-Odescalchi Castle. Explore the highlights of Southern Italy and the best of Sicily as you drive through diverse.. An open jaw means you fly into one city, and depart from another. That will get you to Europe, and back. Example: Outbound: LA to Rome. Inbound: Catania to LA. Step 2) Book a European “hopper” flight. These mini flights will let you travel within Europe, for el cheapo, and shorten travel times.
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Alitalia, Ryanair and two other airlines fly from Rome to Palermo hourly. Alternatively, Trenitalia Intercity operates a train from Roma Termini to Palermo Centrale once daily. Tickets cost €50 – €70 and the journey takes 11h 38m. Airlines.. What companies run services between Italy and Sicily, Italy? easyJet, Neos and Ryanair fly from Naples to Catania 5 times a day. Alternatively, Trenitalia Intercity operates a train from Roma Termini to Palermo Centrale once daily. Tickets cost €50 – €70 and the journey takes 11h 38m. Airlines. easyJet. Ryanair.

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